The Rotterdam Study

The Rotterdam Study

Rotterdam StudyThe Rotterdam Elderly Study is a prospective cohort study in the Ommoord district in the city of Rotterdam, the Netherlands. Following the pilot in 1989, recruitment started in January 1990. The main objectives of the Rotterdam Study were to investigate the risk factors of cardiovascular, neurological, ophthalmological and endocrine diseases in the elderly. Up to 2008, approximately 15,000 subjects aged 45 years or over have been recruited. Participants were interviewed at home and went through an extensive set of examinations, bone mineral densiometry, including sample collections for in-depth molecular and genetic analyses. Baseline data collection was performed from October 1990 to July 1993.

Examinations were repeated every 3-4 years in potentially changing characteristics. Participants were followed for the most common diseases in the elderly, including coronary heart disease, heart failure and stroke, Parkinson’s disease, Alzheimer’s disease and other dementias, depression and anxiety disorders, macular degeneration and glaucoma, diabetes mellitus and osteoporosis. Morbidity and mortality is registered through general practitioners practices. Events are coded according to the International Classification for Primary Care (ICPC) and tenth edition of the International Classification of Disease (ICD) using clinical information obtained from the general practitioner and hospital discharge records. The Rotterdam Study has been published extensively in both the national and international scientific literature.

Our resources are also based on scientific findings from a large prospective cohort study in children, Generation R.