Generation R

Generation R

Generation RThe Generation R Study is a prospective cohort study from fetal life until young adulthood in a multi-ethnic urban population. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participated in the study. The study was designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on growth and physical development, behavioral and cognitive development, asthma and atopy, diseases in childhood and (health)care. Until now measurements have been done up till the age of 9. Linking the data from nine year olds to the data already collected during pregnancy and the first years after birth, gives a unique picture of the growth, development and health until the age of ten years.

At baseline, data collection was done using physical examinations, questionnaires, fetal ultrasound examinations and biological samples. In the preschool period, data collection in this phase included neuromotor development assessment, physical examinations, questionnaires and hands on assessments and observations in a subgroup of children. At the age of 5 years, all children were invited to visit the Generation R research center for detailed assessments: hands on measurements, behavioral observations and biological sample collection. From the age of 9 years onwards, all participating children and their mothers are invited to the Generation R research center again. In this research phase, hands-on measurements, behavioral observations and biological sample collection are continued. Also MRI scans are taken of all participating children in order to examine brain, lungs and the cardiovascular system. Results from Generation R have been published in national and international journals.

Our resources are also based on scientific findings from a large prospective cohort study in the elderly, The Rotterdam Study.